|
KMID : 0811720040080000192
|
|
Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.192 ~ p.0
|
|
|
The Alteration of Annexin 1 Expression in the Spinal Cord Following Intra-articular Injection of Carrageenan in Rats
|
|
Lee Young-Hyurk
Lee Kyu-Sang
Zhang Guo-Hua
Han Hee-Chul
|
|
|
Abstract
|
|
|
It has been known that different annexins are expressed in various cell types in mammalian nervous system. Furthermore, annexin 1 has been demonstrated to have anti-inflammatory effect in experimental arthritis. So, the patterns of annexin 1 expression in the spinal cord may change during the development of arthritis. To clarify the relationship of spinal annexin 1 expression with response to injury and the progressing of arthritis, we compared the change of annexin 1 expression in the spinal cord at different time points after carrageenan injected into knee joint using immunohistochemistry. Our results showed that annexin 1 expression was significantly increased at the ipsilateral side to carrageenan injection at 8 h and on 1 and 3 days after carrageenan injection, and peaked on 1 day. The data in the present study suggest that annexin 1 in the spinal cord may be involved in neuronal and/or glial responses to acute arthritis and may contribute to the endogenous protection from various injury.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S141-S141
|
|
|
KEYWORD
|
|
|
Annexin 1, Carrageenan, Arthritis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|